Spontaneous Tumors in Sprague-Dawley JCL Rats
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چکیده
منابع مشابه
Spontaneous tumors in Sprague-Dawley rats and Swiss mice.
A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used as untreated control animals in an 18month series of carcinogenesis experiments. The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high inci...
متن کاملSpontaneous Tumors in Sprague-Dawley Rats and Swiss Mice1
A spontaneous tumor incidence of 45% was noted in 360 Sprague-Dawley rats (179 males and 181 females) and a 26% incidence was seen in 254 Swiss mice (101 males and 153 females) used as untreated control animals in an 18month series of carcinogenesis experiments. The percentage of female rats with tumors was almost double that of males, which difference was accounted for chiefly by the high inci...
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Spontaneous renal tubule tumors (RTTs), with a distinctive morphological phenotype, were present in three Sprague-Dawley rats, 1 male and 2 females, out a total of 120 animals of each sex from untreated and placebo control groups in a 2-year carcinogenicity study. One female had one carcinoma, adenoma and hyperplasia, and the other female had five adenomas and many hyperplastic lesions; the mal...
متن کاملSpontaneous neoplastic lesions in aged Sprague-Dawley rats.
Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in ma...
متن کاملSpontaneous Thymoma in a 10-Week-Old Sprague-Dawley Rat
Spontaneous thymoma was found in the left lobe of the thymus of a male 10-week-old Sprague-Dawley (SD) rat. Microscopically, the thymic mass showed a sheet of dark area with multiple pale foci. The dark area mainly consisted of densely compacted small lymphoid cells with sporadic large epithelioid cells and mitotic figures. The epithelioid cells and mitotic figures were more frequent than those...
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ژورنال
عنوان ژورنال: EXPERIMENTAL ANIMALS
سال: 1973
ISSN: 0007-5124,1884-4170
DOI: 10.1538/expanim1957.22.2_127